Antibiotic dosages for obese patients might require personalization, studies recommend
Obesity's influence on antibiotics can lead to unpredictable drug exposure, affecting both effectiveness and dosage requirements, according to a new study in The Lancet Infectious Diseases. This research aimed to provide guidelines for prescribing antibiotics to obese patients by reviewing studies on dosing and antibiotics.
The team of medical researchers proposed consensus guidelines for antibiotic prescriptions, noting that obesity alters how antibiotics are distributed within the body due to physiological changes like increased body composition or organ dysfunction. As a result, obese patients may need higher drug dosages and antibiotics with better tissue penetration to combat these changes.
Mahyar Etminan, a drug safety epidemiologist, explained that efficient antibiotic distribution in obese individuals relies on higher doses, more penetrating antibiotics, and additional considerations. However, certain antibiotic classes, like β-lactams, do not necessitate weight-based adjustments, according to the review.
On the other hand, aminoglycosides and glycopeptides, often prescribed for severe infections, require weight-based dosing to achieve therapeutic levels. Therapeutic drug monitoring and monitoring kidney function are recommended for these antibiotics to ensure effective dosing.
Overall, the research emphasizes the need for individualized therapy, close monitoring, and potentially tailored dosing strategies in obese patients to minimize risks of underdosing and overdosing.
Higher Doses May Be Needed
Obesity increases body mass, making it challenging for the drug to reach the required tissue levels. Higher doses and antibiotics with higher tissue penetration are often necessary to compensate.
Special Attention for β-Lactams and Aminoglycosides/Glycopeptides
β-lactams may require more individualized dosing in obese patients, as some recent studies show lower effectiveness in this patient group. In contrast, aminoglycosides and glycopeptides necessitate weight-based dosing to account for the volume of distribution increase and potential kidney function changes.
While robust data on other antibiotic classes is limited, the team encourages careful decision-making concerning dosing in obesity, considering illness severity, infection site, pathogen susceptibility, and potential toxicity.
Ultimately, the study suggests that close monitoring and individualized therapy are essential to optimizing outcomes in obese patients.
Led by Anne-Grete Märtson of Leiden University in the Netherlands, the research team reviewed over 6,000 studies on obesity and antibiotic dosing, ultimately identifying 128 that met the criteria for their research.
As more research emerges for different antibiotic classes, the team hopes to establish clearer and more conclusive guidelines for dose adjustments in obese patients.
- The influence of obesity on antibiotics can lead to unanticipated drug exposure, impacting both effectiveness and dosage requirements.
- This study in The Lancet Infectious Diseases aimed to provide guidelines for prescribing antibiotics to obese patients.
- The researchers proposed consensus guidelines for antibiotic prescriptions, acknowledging that obesity alters antibiotic distribution due to physiological changes.
- Higher doses of antibiotics are often necessary in obese individuals to compensate for increased body mass.
- Antibiotics with better tissue penetration may also be required to combat the changes caused by obesity.
- Efficient antibiotic distribution in obese individuals relies on higher doses, more penetrating antibiotics, and additional considerations.
- Certain antibiotic classes, like β-lactams, do not necessarily require weight-based adjustments, according to the review.
- However, aminoglycosides and glycopeptides, often prescribed for severe infections, require weight-based dosing to achieve therapeutic levels.
- Therapeutic drug monitoring and monitoring kidney function are recommended for these antibiotics to ensure effective dosing.
- The research emphasizes the need for individualized therapy, close monitoring, and potentially tailored dosing strategies in obese patients.
- Obesity increases the volume of distribution and can potentially affect kidney function, necessitating weight-based dosing for certain antibiotics.
- β-lactams may require more individualized dosing in obese patients due to lower effectiveness in this patient group, according to some studies.
- Careful decision-making concerning dosing in obesity should consider illness severity, infection site, pathogen susceptibility, and potential toxicity.
- The study highlights the importance of close monitoring and individualized therapy in optimizing outcomes for obese patients.
- The research team led by Anne-Grete Märtson reviewed over 6,000 studies on obesity and antibiotic dosing to identify the most relevant for their analysis.
- As more research emerges for different antibiotic classes, the team hopes to establish clearer and more conclusive guidelines for dose adjustments in obese patients.
- This research is significant for the news in the health and wellness industry, especially for workplace-wellness initiatives.
- Understanding the impact of obesity on antibiotic dosing can contribute to better treatments and patient care.
- In the realm of medical conditions, chronic diseases, cancer, respiratory conditions, digestive-health issues, eye-health problems, hearing disorders, and neurological disorders, this research could have implications for drug administration.
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- The stock-market, private-equity, and venture-capital industries may show interest in companies developing therapies-and-treatments for obesity-related drug distribution issues.
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- In the broader context of the environment and the neurological health of the planet, this research adds to the discussion on environmental-science, shedding light on the impact of antibiotic resistance and its potential links to climate-change.
