Blood Pressure Management: New Medication Demonstrates Prominent Efficacy
A game-changer in high blood pressure treatment:
A breakthrough in managing hard-to-control high blood pressure has surfaced from a global clinical trial, offering hope to millions worldwide.
Lorundrostat, an aldosterone synthase inhibitor, was found to safely and consistently lower blood pressure in various patients who didn't respond to other medications, marking a significant milestone in the development of first-ever targeted aldosterone synthase inhibitors.
Hypertension—the silent killer—plagues millions across the globe, raising the risk of heart disease, heart attacks, and strokes. Resistant hypertension, a form of uncontrollable high blood pressure, affects up to 15% of all hypertension cases. That's when aldosterone, a hormone regulating blood pressure, becomes dysregulated, leading to hypertension.
Presented at the 34th European Meeting on Hypertension and Cardiovascular Protection, the ground-breaking study showcases lorundrostat's potential in treating uncontrolled or resistant hypertension.
How does lorundrostat work?
Lorundrostat specifically targets and inhibits CYP11B2, the enzyme driving aldosterone production. By doing so, it lowers aldosterone levels and, consequently, blood pressure.
In the Launch-HTN trial, consistent reductions in blood pressure were observed in a large, diverse group of patients.
According to Manish Saxena, MD, lead Investigator of the study, "Lorundostat has good safety and lowered blood pressure consistently in all patient groups."
Lorundrostat in action:
Administered once daily at a 50 mg dose, lorundrostat showed impressive and sustained reductions in systolic blood pressure. Week 6 saw a 16.9 mmHg drop, and the reduction reached 19 mmHg by Week 12, compared to a 9.1 mmHg reduction at Week 6 and 11.7 mmHg reduction at Week 12 for placebo.
These findings confirm lorundrostat's effectiveness in a diverse patient group with difficult-to-control hypertension.
A new weapon against the silent killer:
Aldosterone synthase inhibitors, like lorundrostat, could serve as a vital addition to hypertension treatment options, helping decrease hypertension rates and improving health outcomes.
Two experts, not involved in the study, echoed these sentiments. Cheng-Han Chen, MD, noted, "Lorundrostat is one step closer to having another tool in our arsenal for patients with difficult-to-control blood pressure."
Rigved Tadwalkar, MD, FACC, added, "If lorundrostat becomes widely available, it could make a real difference in patients' lives."
As we continue to grapple with the challenges of hypertension management, lorundrostat's efficacy and safety profile could pave the way for more personalized, mechanism-specific care.
Enrichment Data:
Overall:
Lorundrostat is an aldosterone synthase inhibitor (ASI) that targets the production of aldosterone, a hormone involved in blood pressure regulation. By inhibiting the enzyme CYP11B2, lorundrostat reduces the production of aldosterone, thereby lowering blood pressure in patients with resistant or uncontrolled hypertension1.
Efficacy Findings:
In the largest Phase 3 trial (Launch-HTN) to date for this class of treatment, lorundrostat demonstrated significant and sustained reductions in systolic blood pressure. When administered at a dose of 50 mg once daily, lorundrostat achieved a 16.9 mmHg reduction in systolic blood pressure at Week 6 and a 19.0 mmHg reduction at Week 12, compared to placebo-adjusted reductions of 9.1 mmHg and 11.7 mmHg, respectively2.
Safety and Tolerability:
Lorundrostat has shown a favorable safety and tolerability profile in large, diverse patient groups. The Launch-HTN trial recruited over 1,000 participants with uncontrolled or resistant hypertension, indicating that lorundrostat is well-tolerated when added to existing antihypertensive treatments1.
Clinical Implications:
The consistent blood pressure reductions across diverse patient populations highlight lorundrostat's potential as an effective treatment for resistant hypertension. Its mechanism of action and efficacy suggest it could be a valuable addition to existing hypertension management strategies1.
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