Strong Results Demonstrated by New Drug for Effective Blood Pressure Management

Strong Results Demonstrated by New Drug for Effective Blood Pressure Management

A groundbreaking development in managing tricky-to-manage high blood pressure has surfaced, as findings from a substantial global clinical trial indicate that lorundrostat - an aldosterone synthase inhibitor - is both safe and highly effective in a broad collection of patients resistant to other medications. This affirmation signals a vital advancement in the development of the first targeted aldosterone synthase inhibitor for these conditions.

Hypertension, or high blood pressure, occurs when the force of blood against your artery walls is consistently higher than standard levels. This widespread condition significantly raises the risk of cardiovascular disease, heart attacks, and strokes. Resistant hypertension - a form of the condition - persists despite a person taking three different blood pressure medications at their maximum recommended doses, affecting up to 15% of those with hypertension.

A new study, featured at the 34th European Meeting on Hypertension and Cardiovascular Protection, showcases lorundrostat's potential as a versatile solution for patients battling uncontrolled or resistant high blood pressure. The findings have not yet been published in a peer-reviewed journal.

So, how exactly does lorundrostat work its magic? Lorundrostat is meticulously engineered to halt aldosterone production by targeting and inhibiting CYP11B2, the enzyme that drives its creation. The exploration revealed consistent decreases in blood pressure across various patient groups worldwide, standing as the largest phase three trial to date for this class of treatment.

Manish Saxena, MD, Clinical Co-Director of the William Harvey Heart Centre at Queen Mary University of London and Hypertension Specialist from Barts Health NHS Trust, who lead the study, explains:

"For far too long, more than one-third of adults worldwide struggling with hypertension are not reaching their blood pressure goal. The aldosterone pathway plays a significant role in blood pressure regulation and results in complications like heart failure and kidney issues. In the Launch-HTN trial, we investigated the safety and effectiveness of lorundostat, a new class of drugs called aldosterone synthase inhibitors that suppress the production of aldosterone from the adrenal glands."

Lorundrostat exhibited sustained efficacy in patients with resistant hypertension, as demonstrated by the Launch-HTN trial. The study was a global, Phase 3 investigation, randomized, double-blind, and placebo-controlled. It included adults with uncontrolled blood pressure despite taking two to five antihypertensive medications. Designed to reflect real-world clinical practice, the trial used automated office blood pressure (AOBP) measurements and allowed participants to continue their existing treatments.

Administrated once daily at a 50 mg dose, lorundrostat demonstrated meaningful and sustained reductions in systolic blood pressure: a drop of 16.9 mmHg at Week 6 (a 9.1 mmHg reduction compared to placebo) and by 19 mmHg at Week 12 (an 11.7 mmHg reduction versus placebo).

Two experts, not affiliated with the study, also provided their insights. Cheng-Han Chen, MD, board-certified interventional cardiologist, and medical director of the Structural Heart Program at MemorialCare Saddleback Medical Center in Laguna Hills, CA, highlighted that "aldosterone synthase inhibitors are a new class of drugs being studied for the treatment of hypertension."

"With lorundrostat, one step closer to having another tool in our arsenal for patients struggling to control their blood pressure despite being on multiple medications," Chen shared. "Many patients continue to experience high blood pressure despite taking several medications. The availability of another class of blood pressure medications will help us more successfully manage blood pressure, thus improving overall health outcomes."

Rigved Tadwalkar, MD, FACC, consultative cardiologist, and director of Digital Transformation at Pacific Heart Institute in Santa Monica, CA, argued that this is a significant stride forward.

"We still confront a substantial number of patients with uncontrolled or resistant hypertension, even when they're on multiple medications. The fact is that for a substantial subset of these patients, aldosterone is the primary culprit, and until now, we haven't had a practical method to directly target that mechanism. Lorundrostat seems to have done precisely that. It inhibits aldosterone synthesis at the enzymatic level, and based on this trial, it does so with a positive safety profile and consistent efficacy across various patient groups."

The experts believe that lorundrostat may bring genuine change in patients' lives, offering a novel treatment option for those who've exhausted standard pathways. For individuals with resistant hypertension, often managing co-morbidities like kidney disease or heart failure, having another tool, especially one that addresses the underlying hormonal imbalance, could improve long-term outcomes.

1. This breakthrough development in managing hypertension centres around lorundrostat, an aldosterone synthase inhibitor, found to be both safe and highly effective in a diverse group of patients.
2. Science advances continue to shape health and wellness, with lorundrostat demonstrating potential as a versatile solution for those battling uncontrolled or resistant high blood pressure.
3. In a global clinical trial, lorundrostat has proven consistent decreases in blood pressure across various patient groups worldwide, marking a significant milestone in the development of aldosterone synthase inhibitors.
4. Hypertension, a widespread medical condition, significantly increases the risk of cardiovascular disease, heart attacks, and strokes.
5. Resistant hypertension, a form of the condition, persists despite a person taking three different blood pressure medications at their maximum recommended doses.
6. A new study, presented at the 34th European Meeting on Hypertension and Cardiovascular Protection, showcases lorundrostat's potential as a groundbreaking treatment for resistant hypertension.
7. Lorundrostat works by meticulously targeting and inhibiting CYP11B2, the enzyme that drives aldosterone production.
8. The Launch-HTN trial, a global, Phase 3 investigation, underscored lorundrostat's sustained efficacy in patients with resistant hypertension.
9. The study included adults with uncontrolled blood pressure despite taking two to five antihypertensive medications.
10. In real-world clinical practice, the trial used automated office blood pressure (AOBP) measurements and allowed participants to continue their existing treatments.
11. Administered once daily at a 50 mg dose, lorundrostat demonstrated meaningful and sustained reductions in systolic blood pressure.
12. Men's health and women's health alike stand to benefit from this novel treatment option for resistant hypertension.
13. With lorundrostat, we may witness genuine change in patients' lives, offering a new solution for those who've exhausted standard pathways.
14. Healthcare professionals may find lorundrostat a valuable addition to their arsenal in managing co-morbidities associated with resistant hypertension, such as kidney disease or heart failure.
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29. As the application of lorundrostat and similar treatments unfolds, individuals must stay informed and advocate for their health by leveraging resources such as Medicare, staying up-to-date on research, and collaborating with healthcare professionals to make informed decisions about their health and wellness.

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